^{11th International Conference on} Pharmacoepidemiology and Clinical Research October 02-03, 2017 Kuala Lumpur , Malaysia

Biography:

Prof. Noorizan is a Professor in Clinical Pharmacy, Faculty of Pharmacy, Universiti Teknologi MARA(UiTM), Malaysia. Graduated in  Master of Science, Radiopharmacy, from University of Southern California,1983 and PharmD, from University of Minnesota, USA,1985. She has been teaching  Pharmacy more than 30 years at University Sains Malaysia(USM),Universiti Teknologi MARA(UiTM) and Management and Science University (MSU). Her current research interest  focus on clinical pharmacy, pharmacoepidemiology, pharmaceutical outcome study, pharmacy practice and halal pharmaceuticals. Involved She also National Committee of Halal Pharmaceutical Products and Assessor Panel for National Research Grant. She is a preceptor for Critical Care, infectious Disease and Nephrology Pharmacy for undergraduate and clinical pharmacy post-graduate students.  

Abstract:

Cutaneous skin reaction it the most reported cases based on the spontaneous adverse drug reactions (ADRs) reported in Malaysia 2015. Stevens-Johnson Syndrome (SJS) is the rare cutaneous skin reaction but fatal, involving skin and mucous membrane following consumption of certain drugs. SJS is defined as skin detachment of less than 10% of the total body surface area. This study was aimed to determine the SJS induced by the drug in Malaysia (2011-2015) in terms of incidence, age, race, gender and extent of disease severity, common drug–induced SJS and the associating factors.  This is a retrospective study and data was collected at Pharmacovigilance Section, National Pharmaceutical Regulatory Agency (NPRA). The total of 2011 cases of ADRs reports retrieved from Quest 2 database. After the application of the exclusion and inclusion criteria, 661 SJS cases were found out of 48,306 ADR cases reported.The mean incidence is 4.25 % (ranged from 3.05-5.05), female patients had slightly higher incidence of SJS (n=387, 50.5%), Malay Patients the highest (58.5%) and the highest age range is between 31 to 45 years old (24. 1%).About half of SJS cases, 49.2% (n=325) cases were classified as having severe SJS. The extent or degree of SJS severity was no association with gender (n=483, râ‚œ = -0.040, p = 0.370), race (n=468, râ‚œ = 0.058, p = 0.175) and groups of age (n=484, râ‚œ = -0.033, p = 0.400) using a Kendall Tau-b analysis. The first 3 frequent drugs associated with SJS is Allopurinol with 131 cases (19.8%), followed by carbamazepine (n=107, 14.80%) and phenytoin (n=73, 10.10%).Allopurinol and epileptic drugs are the frequent drugs caused SJS. Social demographic data that been studied has no association with the extent of SJS severity.

Biography:

Khalid A Al-Sunaidar is currently working as Faculty of Pharmacy at Universiti Teknologi MARA, Malaysia. His area of research is adequacy of empirical antibiotics in ICU sepsis patients.

Abstract:

Sepsis affects over 26 million people worldwide each year causing death every 3 to 4 seconds. It is considered as the top cause of morbidity and mortality in clinical settings. Severity score system is used to predict the mortality in hospitalized critically ill patients. The most common used scoring system is The Acute Physiology and Chronic Health Evaluation (APACHE). This study aimed to determine the association of sepsis treatment in adult’s ICU patients on severity index APACHE scores and their predicators or clinical outcomes. A retrospective study was conducted in critically ill adult patients with sepsis in the ICU of Sungi Boluh Hospital. Data were retrieved from the patients’ records. The univariate and multivariate linear regression analyses with cox regression modeling were performed to compute the adjusted association of sepsis treatment on ICU-mortality. The result showed that out of 228 ICU adults patients, 193 (84.6%) died. In univariate linear regression, there were 28 significant predicators of severity APACHE scores variation. Among 28 variables the most two contributed variables which were shared in explanation of the variation of increment of APACHE score (mechanical ventilation support and renal failure development) R²=0.029 and B coefficient=13.717 (95% CI: 3.366-24.067; P=0.010), R²=0.205 and B coefficient=9.285 (95% CI: 6.890-11.680; P=0.000), respectively. However, for the multivariate linear regression model, only 2 variables were more likely associated as predicators for increment of APACHE scores (septic shock diagnosis and CRRT supported patients) with R²=0.779, B coefficient=5.344 (95% CI: 1.077-9.610; P=0.016) and B coefficient=4.124 (95% CI: 1.078-7.171; P=0.009), respectively. In the univariate cox regression, receiving mechanical ventilation (MV) for 1-3 days has risk of death HR 40.524 (95% CI 5.383-305.076, P=0.000), and in MV for 4-6 days HR 10.025, 95% (CI 1.364-73.695, P=.024) respectively. Additionally, the sepsis induced organ failures (4 organs) has risk of death HR 1.820, 95% (CI 1.067-3.106, P=0.028). DVT develop Disease HR 1.676, 95% (CI 1.225-2.294, P=0.001). Intermittent dialysis HR 0.340, 95% (CI.228-0.507, P=0.000). While in the multivariate cox regression, the organ dysfunction (4 organs) was the protective factor for mortality with HR 0.128, 95% (CI: 0.025-0.654; P=0.014) as well as the intermittent dialysis HR 0.027, 95% (CI: 0.002-0.321, P=0.004), respectively. Regarding the survival estimation Kaplan-Meier, the intermittent dialysis was significantly associated with the survival with the Log Rank (Mantel-Cox) χ²=27.831 (95% CI: 13.172-18.828; P=0.000). Additionally, patients who received DVT treatment was significantly associated with the survival with the Log Rank (Mantel-Cox) χ²=12.285 (95% CI: 8.197-11.803; P=0.000). The septic shock and CRRT therapy were predictors for increasing severity index scores. However, the MV received for 1-6 days and sepsis induced four organs failure were risk factors for ICU mortality.

Biography:

Ph.D., M. Pharm. (Pharm. Chemistry), B. Pharm. and PGDMM from Dr. H. S. Gour Central University, Sagar, India; More than 18 years of teaching and research experience with keen interest and expertise of research in Photodynamic therapy. Carrier: Presently working as Principal, Metro College of Health Sciences and Research, Metro College of Pharmacy, Greater Noida, India. Selected Awards: Junior research fellowship by UGC during Ph. D, best oral presentation by Department of Botany, Dr. H. S. Gour Central University, Sagar, India. Membership: Indian Association for Cancer Research, The Association of Pharmaceutical Teachers of India, Indian Science Congress Association, Indian Chemistry Teachers Association, International Society for Infectious Disease. Editorial Board Member: Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry, Publications and Presentations: various National and International conferences: 37, Orientation Programmes: 04, Guided PG: 10 Expert Talks: 05

Abstract:

Biography:

Dr. Al-Azayzih is currently an Assistant Professor in the Department of Clinical Pharmacy at Jordan University of Science and Technology. His current Research projects focuses on understanding the molecular mechanisms governing Prostate and Bladder Cancer progression, tumor angiogenesis and metastasis, and identifying newer therapeutics strategies to manage both cancers. He earned his Doctor of Pharmacy (PharmD) Degree from Jordan University of Science and Technology in 2007. He then earned a Ph.D. in Clinical and Experimental Therapeutics from the University of Georgia- College of Pharmacy in 2014.Dr. Al-Azayzih is a Board Certified in Oncology Pharmacy since May, 2014.  Dr. Al-Azayzih has authored has authored 12 original research publications in various Journals including biochemical biophysical acta, Nanomedicine, Journal of Biological Chemistry, Journal of Clinical and Experimental Therapeutics, and others. He has authored more than 25 abstracts presented in local, national and international conferences and received several awards for research and academic excellence

Abstract:

Clopidogrel is considered one of the most important drugs used either alone or in combination with aspirin to reduce the risk of major cardiovascular conditions including heart diseases and stroke, and in patients who receive coronary stents after myocardial infarction. Recent studies have shown that clopidogrel efficacy might be affected by co-prescribing of proton pump inhibitors (PPIs), such as omeprazole and esomeprazole as they inhibit the CYP2C19 enzyme, which is necessary for clopidogrel biotransformation and activation in the body. So, co-administration of both drugs might decrease the clopidogrel antiplatelet activity and sub-therapeutic effects in those patients who use clopidogrel. Objective: the main objective of our study is to evaluate the prevalence of co-prescribing of both clopidogrel and PPIs among patients who are treated in a number of Jordanian hospitals (Albashir Hospital, King Abdullah University Hospital, Al-Karak Hospital, and Prince Hamza Hospital). Method: this study is a cross-sectional study conducted over a period of 100 days. It involves a total number of 18303 patients from both genders who are visited the outpatient pharmacies in those hospitals. Results: Of 18303 patient’s records studied, a total number of 438 patients were prescribed clopidogrel, of which 238 were prescribed aspirin also, and 103 patients had received clopidogrel and PPIs (any) together. Among those who were prescribed clopidogrel and PPIs, 82 patients received lansoprazole, 6 patients received esomeprazole, and 15 patients received omeprazole. We further categorized the patients who are taking clopidogrel and PPIs based on their diabetic status as diabetes, known to increase the risk of cardiovascular conditions. A total number of 25 and 78 patients who received the combination of clopidogrel and PPI (any) were diabetic and non-diabetic, respectively. Conclusion: a large number of patients were prescribed a combination therapy of clopidogrel and PPIs (any). It is very important to either quit such co-prescribing behavior, especially, when they are not necessary (e.g, using clopidogrel alone without aspirin). Also, using the PPIs with the lowest inhibitory effect on CYP2C19, such as pantoprazole and rabeprazole are considered to be better alternatives.

Biography:

Sami Mohammed Albawani is a Phd candidate in department of pharmacology at University Teknologi MARA, Malaysia .

Abstract:

As health care professionals, pharmacists are ideally located in community to ensure safe, effective, and rational use of drugs during self-medication practice. However, the profession of pharmacist in Yemen has become less trustworthy and many drugs are dispensed without any medical supervision. The purpose of this study is to investigate the role of community pharmacists and other drug dispensers during self-medication practice. Methods: An in depth, semi-structured interviews including a series of open-ended questions were conducted and twenty community drug dispensers working in ten community pharmacies in Sana'a City were recruited based on purposive sampling technique. All interviews were audio recorded, transcribed verbatim and translated to English. The transcripts were analyzed thematically using constant comparison approach. Results: Many important themes were identified including the irrational dispensing practice by drug dispensers, poor quality of education, lack of trust towards pharmacists and doctors. Conclusion: There is an urgent need for educational campaigns to increase awareness among drug dispensers toward the risk of irresponsible self-medication. Only qualified pharmacists should be allowed to dispense medications, pharmacy curriculum need to be reviewed and updated to address important health issues including self-medication and health authorities must urgently ensure the enactment of pharmacy law.

Biography:

Dr. Ankur Vaidya did his graduation, post graduation and PhD from Deptt. of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (M.P.) in 2004, 2008 and 2013 respectively. Dr. Vaidya has a teaching and research experience of more than 8 years and is currently working as Asst. Professor in Pharmacy College UPRIMS and R Saifai, Etawah (U.P.). Dr. Ankur has a key research interest in QSAR, Drug design, synthesis of new drugs, Instrumentation (UV, IR, NMR and Mass spectroscopy) and New Chemical Entities (NCE) for Anticancer activity. Dr Vaidya has credited as reviewer of international journals of repute in the field of Pharmaceutical sciences. He was the recipient of AICTE-NDF (National Doctorate Fellowship) fellowship for PhD research project and UGC fellowship for his M.Pharm project work. Dr. Ankur has participated/presented in various National and International conferences held in India. 

Abstract:

As a continuation of our efforts to discover and develop the 1,2,4-oxadiazole derivatives as potential anticancer agents, presently we explored substitutions at the 3^rd and 5^th position of 1,2,4-oxadiazoles toenhancetheanticancerpotential ofsynthesizedcompounds.Formationof3aryl5aryl1,2,4oxadiazoleswereaccomplishedbythereactionofsubstitutedarylcarbonylchloridewithsubstitutedhydroxybenzamidineorhydroxypyridinecarboxamidine. The in vitrocytotoxic effects of 3-aryl-5-aryl-1,2,4-oxadiazoles have demonstrated across a array of tumor cell types and a fewcompounds(2AA,1CC,1AAand1BB)exhibitedhighestanticancer potential against different cancer (DLD1, T47D, CaCo-2 and PC-3) cell lines respectively.