Ankur Vaidya
Uttar Pradesh University of Medical Sciences, India
Title: Design and synthesis novel 1,2,4-Oxadiazole derivatives as potent anti cancer agents
Biography
Biography: Ankur Vaidya
Abstract
As a continuation of our efforts to discover and develop the 1,2,4-oxadiazole derivatives as potential anticancer agents, presently we explored substitutions at the 3rd and 5th position of 1,2,4-oxadiazoles toenhancetheanticancerpotential ofsynthesizedcompounds.Formationof3aryl5aryl1,2,4oxadiazoleswereaccomplishedbythereactionofsubstitutedarylcarbonylchloridewithsubstitutedhydroxybenzamidineorhydroxypyridinecarboxamidine. The in vitrocytotoxic effects of 3-aryl-5-aryl-1,2,4-oxadiazoles have demonstrated across a array of tumor cell types and a fewcompounds(2AA,1CC,1AAand1BB)exhibitedhighestanticancer potential against different cancer (DLD1, T47D, CaCo-2 and PC-3) cell lines respectively.